This book constitutes the refereed proceedings of the Fourth
International Symposium on Bioinformatics Research and Applications,
ISBRA 2008, held in Atlanta, GA, USA in May 2008. The 35 revised full
papers presented together with 6 workshop papers and 6 invited papers
were carefully reviewed and selected from a total of 94 submissions. The
papers cover a wide range of topics, including clustering and
classification, gene expression analysis, gene networks, genome
analysis, motif finding, pathways, protein structure prediction, protein
domain interactions, phylogenetics, and software tools.